Calisthenics Versus High-intensity Interval Exercises on Health-related Outcomes in Patients With Non-alcoholic Fatty Liver

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

According to sample size calculation and after achieving the inclusion criteria, sixty patients with non-alcoholic fatty liver (NAFL) of both genders will be enrolled in this study and their ages will be ranged from30s-40s; they will be selected from internal medicine-outpatient clinics, Cairo University Hospitals; they will participate in the study for 8 weeks, and randomly be assigned into two equal groups in number. Group (A) (n =30) will receive calisthenics exercise three times /week for eight weeks, group (B) (n =30) will receive HIIT for three times /week for eight weeks and all patients in both groups will receive their prescribed medication (Statin 5mg ).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 45
Healthy Volunteers: f
View:

• 1\. Sixty patients with non-alcoholic fatty liver disease (NAFLD) of both genders.

• 2\. Patients with mild non-alcoholic fatty liver disease (NAFLD) according to ultrasonography fatty liver indicator (US-FLI) score (2-4).( Chen et al.,2020) 3. Their age will be ranged from 30s-40s. 4. Body mass index (BMI) from 30 to 34.9 kg/m2. 5. Body free fat mass (FFM) percentage \> 25 % for men,\> 35 % for women. 6. Lean body mass (LBM) parentage \< 76 % for men; \< 69% for women. 7. Waist circumference ≥ 102 cm for men, \> 88 cm for women. 8. Waist/Hip ratio \> 0.9% for men and \> 0.8% for women. 9. Elevated liver enzymes (ALT\> 55 U/L, AST\> 48 UL, GGT\>85 U/L, AST/ALT \<1 U/L).

• 10\. Patient with dyslipidemia who has one or more from the following blood lipid values (total cholesterol \> 200 mg\dl, LDL \> 130 mg\dl, TG \>150 mg\dl, HDL\< 40mg\dl or LDL/HDL ratio \> 4).

• 11\. Low levels of physical activity (using the International Physical Activity Questionnaire- Short Version (IPAQ)) ≤ 10 min walking per day.

• 12\. Liver size estimated by ultrasonography more than 5% from the normal liver size without hepatocellular damage.

Locations
Other Locations
Egypt
Fatma Younis Mahmoud
RECRUITING
Giza
Contact Information
Primary
Fatma Y mahmoud, AI
drfatmayounis069@gmail.com
+201551832272
Backup
NESREEN G EL-NAHAS, Professor
Nessrien.elnahass@pt.cu.edu.eg
+201002227242
Time Frame
Start Date: 2023-10-15
Estimated Completion Date: 2024-11
Participants
Target number of participants: 60
Treatments
Experimental: Study group A (Calisthenics exercise)
Group (A) (n =30) will receive calisthenics exercise three times /week for eight weeks, patients in this group will receive four forms of calisthenics exercise (squats, curl up, push up, blank) starting free and upgrading intensity according to ability of the patients.
Experimental: Study group B (High intensity interval training)
Group (B) (n =30) will receive high intensity interval training three times /week for eight weeks, A motorized treadmill device (KETTLER, laufband alpha run 600, German) with a minimum speed of 0.5km/hr and capability to display the distance in kilometer per hour will be used in this study. Intensity of HIIT will be measured using Bruce protocol to calculate target heart rate of each patient.
Related Therapeutic Areas
Sponsors
Leads: Cairo University

This content was sourced from clinicaltrials.gov